Jeffrey B. Schineller
My research interests encompass enzymology and design of enzyme inhibitors, bioluminescence, proteomics and identification of biomarkers, interspecies signaling mechanisms, and bacterial secondary metabolites. Current work includes the identification of proteins that bind bacterial quorum sensing signals, the use of proteomics techniques to identify biomarkers for exposure to environmental toxins.
Specialty Area
Biochemistry, Bio-Organic, Enzymology, Proteomics, Quorum Sensing
Education
Postdoctoral Research Associate, Texas A&M University
MS & PhD Chemistry, The Pennsylvania State University
BA Biology & BS Chemistry, Ithaca College
Courses Taught
General Chemistry (CHEM 109)
Organic Chemistry (CHEM 228/228L, 323, 324L, 325L)
Biochemistry (CHEM 434/434L, 435/435L, 438)
Publications
10. Clerc J., Weller, T. J., Schineller, J. B.,Szewczak, J. M. “Minimally invasive collection of adipose tissue facilitates the study of eco-physiology in small-bodied mammals.” Methods in Ecology and Evolution, 2016, 8(1): 109-115.
9. Eberhard, A. & Schineller, J. B. “Chemical Synthesis of Autoinducers and Autoinducer Analogs” Methods of Enzymology, 2000, 305, 301-315.
8. Schineller, J. B. “An Introduction to Enzyme and Coenzyme Chemistry by Timothy Bugg.” Journal of Chemical Education. 1999,76, 1070.
7. Thomas, M. D., Schineller, J. B., & Baldwin, T. O. “Lux Autoinducer Response in Escherichia coli and Vibrio fischeri,” in Bioluminescence and Chemiluminescence, Molecular Reporting with Photons editors J. W. Hastings, L. J. Kricka and P. E. Stanley, J. Wiley & Sons, New York, NY, 1997.
6. Sitnikov, D., Schineller, J. B., Baldwin, T. O. “Control of cell division in Escherichia coli: Regulation of ftsQA involves both rpoS and SdiA-mediated autoinduction.” Proc. Natl. Acad. Sci. U.S.A., 1996, 93, 336-341.
5. Abell, L. M., Schineller, J. B., Keck, P. J., & Villafranca, J. J. "Effect of Metal–Ligand Mutations on Phosphoryl Transfer Reactions Catalyzed by Escherichia coli Glutamine Synthetase," Biochemistry, 1995, 34, 16695-16702.
4. Sitnikov, D., Schineller, J. B., Baldwin, T. O. “Transcriptional Regulation of Bioluminescence Genes from Vibrio fischeri,” Molecular Microbiology, 1995 17, 801-812.
3. Dhalla, A. M., Li, B., Alibhai, M. F., Yost, K. J., Hemmingsen, J. M., Atkins, W. M., Schineller, J. B., Villafranca, J. J. “Regeneration of catalytic activity of glutamine synthetase mutants by chemical activation: exploration of the role of arginines 339 and 359 in activity.” Protein Sci., 1994, 3, 476-81
2. Logusch, E. W., Walker, D. M., McDonald, J. F., Franz, J. E., Villafranca J. J., DiIanni, C. L., Colanduoni, J. A., Li , B., Schineller, J. B. “Inhibition of Escherichia coli glutamine synthetase by alpha- and gamma-substituted phosphinothricins.”
1. Eberhard, A., Widrig, C. A., McBath, P., Schineller J. B. “Analogs of the autoinducer of bioluminescence in Vibrio fischeri.” Arch. Microbiol. 1986, 146, 35-40.
